Name: Artichoke and Spinach Chicken Casserole
Prep time: 15 min
Cook time: 30 min
Total time: 45 min
Cuisine: American
Ingredients: 3 cups cooked, shredded or cubed chicken; 1 (10 oz) package frozen chopped spinach, thawed and drained; 1 (14 oz) can artichoke hearts, drained and chopped; 8 oz cream cheese, softened; 1/2 cup sour cream; 1/4 cup mayonnaise; 2 cloves garlic, minced; 1 cup shredded mozzarella cheese, divided; 1/2 cup grated Parmesan cheese, divided; 1/2 tsp salt; 1/2 tsp black pepper; 1/4 tsp crushed red pepper flakes (optional); 1/2 cup panko breadcrumbs or crushed crackers (optional topping); 2 tbsp butter (for toasting breadcrumbs, optional)

Why You’ll Love This Recipe

Combines creamy dip flavors with protein-rich chicken
Great way to incorporate veggies in a family-friendly meal
Easy to make with simple, pantry-friendly ingredients
Delicious as a weeknight dinner or potluck option
Customizable with different cheeses, add-ins, or toppings

Ingredients

(Tip: You’ll find the full list of ingredients and measurements in the recipe card below.)

Cooked, shredded or cubed chicken (rotisserie works great)
Frozen chopped spinach, thawed and drained
Canned or jarred artichoke hearts, drained and chopped
Cream cheese, softened
Sour cream
Mayonnaise
Garlic, minced
Shredded mozzarella cheese
Grated Parmesan cheese
Salt
Black pepper
Crushed red pepper flakes (optional, for heat)
Panko breadcrumbs or crushed crackers (optional topping)
Butter (for toasting breadcrumbs, if using)

Directions

Preheat the oven to 375°F (190°C) and lightly grease a 9×13-inch baking dish.
In a large bowl, combine cream cheese, sour cream, mayonnaise, garlic, salt, pepper, and red pepper flakes (if using). Mix until smooth.
Stir in spinach, artichoke hearts, chicken, and half of the mozzarella and Parmesan. Mix until evenly combined.
Spread the mixture into the prepared baking dish.
Top with the remaining cheeses and optional breadcrumb topping (toast breadcrumbs in butter first for extra crispiness).
Bake for 25–30 minutes, or until the casserole is hot and bubbly and the top is golden brown.
Let rest for 5–10 minutes before serving.

Servings and timing

This recipe serves 6 people.
Prep time: 15 minutes
Cook time: 30 minutes
Total time: About 45 minutes

Variations

Low-carb/keto: Omit breadcrumbs and ensure all ingredients are keto-friendly.
Add pasta or rice: Mix in cooked pasta or rice to turn this into a one-dish carb-inclusive meal.
Make it spicy: Add chopped jalapeños or a dash of hot sauce.
Use different cheeses: Try Gruyère, white cheddar, or fontina for a flavor change.
Vegetarian version: Omit the chicken and add more spinach or sautéed mushrooms.

Storage/Reheating

Store leftovers in an airtight container in the refrigerator for up to 4 days.
To freeze, let the casserole cool completely, then wrap tightly and freeze for up to 2 months.
Reheat in the oven at 350°F until warmed through, or microwave individual servings for 1–2 minutes, stirring halfway through.

FAQs

Can I use fresh spinach instead of frozen?

Yes, just sauté it first until wilted and squeeze out excess moisture before adding.

What kind of chicken works best?

Cooked shredded or cubed chicken breast or thighs both work. Rotisserie chicken is a great shortcut.

Can I make this ahead of time?

Absolutely. Assemble it up to a day ahead and refrigerate. Bake when ready to serve.

Do I need to cook the artichokes first?

No, canned or jarred artichoke hearts are already cooked—just drain and chop them.

Can I add pasta to this dish?

Yes, stir in 2 cups of cooked pasta before baking for a hearty casserole variation.

What’s the best topping?

Panko breadcrumbs mixed with melted butter and a sprinkle of Parmesan create a golden, crispy topping.

Can I freeze this casserole?

Yes, freeze after baking or before. Thaw overnight and reheat in the oven.

Is this casserole gluten-free?

Yes, if you skip the breadcrumb topping and ensure all ingredients (especially artichokes and mayo) are gluten-free.

Can I use Greek yogurt instead of sour cream?

Yes, Greek yogurt works well as a healthier substitute for sour cream.

How do I make it dairy-free?

Use dairy-free cream cheese, vegan mayo, and non-dairy cheese alternatives.

Conclusion

Artichoke and Spinach Chicken Casserole is a rich, savory dish that turns your favorite appetizer into a complete meal. It’s creamy, cheesy, and loaded with flavor—perfect for cozy dinners, meal prep, or feeding a hungry crowd. With easy customization options and make-ahead convenience, this casserole is sure to become a go-to in your comfort food rotation.